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Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis
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Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi

Carla E Lanze1, Rafael M Gandra1, Jenna E Foderaro1

  • 1Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.

Microbiology and Molecular Biology Reviews : MMBR
|September 17, 2020
PubMed

Insights

Plasma membrane domains called MCC/eisosomes protect cell surface proteins and help fungi respond to environmental stress. These stable membrane compartments are crucial for fungal survival and virulence, offering potential therapeutic targets.

Area of Science:

  • Cell Biology
  • Mycology
  • Biochemistry

Background:

  • Plasma membranes organize cellular functions via specialized domains.
  • The budding yeast *Saccharomyces cerevisiae* features MCC (membrane compartment of Can1)/eisosomes, stable plasma membrane furrows.
  • MCC/eisosomes stabilize cell surface proteins, like the Can1 arginine symporter, preventing degradation.

Purpose of the Study:

  • To review emerging models of MCC/eisosome function in coordinating cellular stress responses.
  • To highlight the role of MCC/eisosomes in lipid homeostasis and cell signaling.
  • To discuss the significance of MCC/eisosomes in fungal virulence and as therapeutic targets.

Main Methods:

  • Review of recent studies on MCC/eisosomes in various fungal species.
  • Analysis of the role of MCC/eisosomes in response to diverse stressors (membrane tension, nutrition, etc.).
  • Examination of the link between MCC/eisosomes, lipid homeostasis, and cell signaling.

Main Results:

  • MCC/eisosomes enable fungal cells to respond to multiple stressors, including nutrient changes, oxidative stress, and copper toxicity.
  • These domains are critical for maintaining plasma membrane integrity and proper cell signaling.
  • MCC/eisosomes play a significant role in the virulence of fungal pathogens.

Conclusions:

  • MCC/eisosomes act as crucial hubs coordinating cellular responses to stress.
  • Lipid homeostasis within MCC/eisosomes is vital for plasma membrane architecture and signaling.
  • MCC/eisosomes represent promising therapeutic targets due to their role in fungal pathogenesis.
Keywords:
Lsp1MCCPil1Slm1Sur7eisosomefurrowmembrane curvaturestressyeast

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