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Updated: Aug 19, 2026

Quantitative Autonomic Testing
Published on: July 19, 2011
RR-variation: the autonomic test of choice in diabetes
1University of Louisville, Louisville Veterans Administration Medical Center, Kentucky 40202.
Abstract:
RR-variation is a sensitive, reproducible, and noninvasive autonomic test. It is simple to perform and easy for both the operator and the subject. Furthermore, RR-variation correlates to known physiologic function. It therefore fulfills many of the characteristics of a practical diagnostic test. Many of the confounding factors are known, and with proper standardization the test may not only have diagnostic capabilities but also predictive value. RR-variation should be included in clinical research trials of diabetic neuropathy and should be considered in routine clinical management of the diabetic patient.
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