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Induction and Analysis of Epithelial to Mesenchymal Transition
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EMT: An Update.

Jean Paul Thiery1

  • 1Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China. bchtjp@nus.edu.sg.

Methods in Molecular Biology (Clifton, N.J.)
|September 17, 2020
PubMed
Summary

Epithelial Mesenchymal Transition (EMT) plays a role in fibrosis and cancer progression. Research shows EMT is not a linear process and involves intermediate states beyond known transcription factors.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Cancer Research

Background:

  • Epithelial Mesenchymal Transition (EMT) is a developmental mechanism.
  • EMT is implicated in fibrosis and carcinoma progression.
  • Novel mechanisms modulating EMT are emerging.

Purpose of the Study:

  • To explore the role of EMT in fibrosis and cancer.
  • To investigate novel mechanisms regulating EMT.
  • To clarify the necessity of EMT in carcinoma cell dissemination.

Main Methods:

  • Analysis of transcription factors involved in EMT.
  • Investigation of intermediate states during EMT.
  • Review of current literature on EMT mechanisms.
Keywords:
CancerEMT spectrumEpithelial-to-mesenchymal transitionFibrosisGastrulationMorphogenesisRibosome biogenesisStemness

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Main Results:

  • EMT is indirectly involved in fibrosis.
  • EMT contributes to carcinoma progression.
  • EMT is not a linear transition and involves intermediate states.
  • Known transcription factors are not always essential for mesenchymal phenotypes.

Conclusions:

  • EMT is a complex process with non-linear transitions.
  • Understanding intermediate EMT states is crucial for cancer research.
  • EMT's role in metastasis requires further investigation.