Lithocaldehydes A and B, polyketones from the deep sea-derived fungus Phomopsis lithocarpus FS508
Huibo Liu1, Zhaoming Liu2, Haohua Li2
1State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China. liuhx@gdim.cn wmzhang@gdim.cn and School of Chemical and Environmental Engineering, Wuyi University, Jiangmen 529020, China.
Abstract:
Lithocaldehydes A (1) and B (2), a pair of novel diastereoisomers possessing an unprecedented 6/6/5/5/6 highly-fused ring system forming an earring-like skeleton, were isolated from the deep sea-derived fungus Phomopsis lithocarpus FS508. The structures of 1 and 2 were fully characterized and established through extensive spectroscopic interpretations and ECD calculations. Moreover, compounds 1 and 2 were shown to be promising antibiotics, exhibiting potent antifungal activities that are comparable to those of the positive control nystatin.
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