Acne related to dietary supplements.

Area of Science:

• Dermatology
• Toxicology
• Nutritional Science

Background:

• Acne vulgaris is a common skin condition with multifactorial etiology.
• The role of prescription medications in acne exacerbation is well-documented.
• Increasing prevalence of dietary supplement use necessitates investigation into their dermatological side effects.

Purpose of the Study:

• To review and summarize the association between various dietary supplements and acneiform eruptions.
• To describe the clinical presentation and potential pathogenesis of supplement-induced acne.
• To emphasize the importance of dermatologists inquiring about supplement use in acne patients.

Main Methods:

• Literature review of studies investigating the link between dietary supplements and acne.
• Analysis of case reports and clinical descriptions of acne related to specific supplements.
• Synthesis of proposed pathogenetic mechanisms for supplement-induced acne.

Main Results:

• Vitamins B6/B12, iodine (kelp), whey protein, and anabolic-androgenic steroids (AAS) in muscle-building supplements are linked to acne.
• Acne presentations vary, including monomorphic lesions, inflammatory pustules, and severe forms like acne fulminans.
• Acne typically resolves upon cessation of the offending supplement.

Conclusions:

• Dietary supplements are an underrecognized cause of acne.
• Dermatologists should routinely screen acne patients for supplement use.
• Patient education regarding potential risks of supplements is crucial for managing acne.