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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Methotrexate and Adalimumab Decrease the Serum Levels of Cardiovascular Disease Biomarkers (VCAM-1 and E-Selectin) in
Natalia Zdanowska1, Agnieszka Owczarczyk-Saczonek1, Joanna Czerwińska1
1Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, 10-229 Olsztyn, Poland.
Psoriasis patients treated with methotrexate or adalimumab showed reduced levels of vascular cell adhesion molecule 1 (VCAM-1) and E-selectin. These markers are linked to cardiovascular disease risk.
Area of Science:
- Dermatology
- Cardiology
- Immunology
Background:
- Psoriasis and atherosclerosis share common pathogenic pathways.
- Endothelial activation molecules may link these conditions.
- Assessing these molecules can elucidate shared pathogenesis.
Purpose of the Study:
- Evaluate serum concentrations of VCAM-1 and E-selectin in plaque psoriasis patients.
- Assess atherosclerosis severity in these patients.
- Determine the impact of methotrexate and adalimumab treatment on these markers.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) used to measure VCAM-1 and E-selectin.
- Study included 34 psoriasis patients and 8 controls.
- Measurements taken at baseline and after 12 weeks of treatment.
Main Results:
- Baseline VCAM-1 and E-selectin levels were higher in the adalimumab group.
- VCAM-1 levels decreased in both methotrexate and adalimumab groups.
- E-selectin levels decreased significantly in the methotrexate group.
Conclusions:
- Systemic psoriasis treatment correlates with changes in VCAM-1 and E-selectin.
- These molecular changes may influence cardiovascular disease risk in psoriasis patients.
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