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Related Concept Videos

Protein Modifications in the RER01:26

Protein Modifications in the RER

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Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
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Catheterization of Intestinal Loops in Ruminants
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Selenosis in Ruminants.

Merl F Raisbeck1

  • 1Department of Veterinary Sciences, College of Agriculture, University of Wyoming, 2852 Riverside, Laramie, WY 82070, USA.

The Veterinary Clinics of North America. Food Animal Practice
|September 18, 2020
PubMed
Summary

Selenium (Se) is a vital nutrient and potential toxicant. Overuse of Se supplements commonly causes selenosis, requiring laboratory confirmation due to overlapping symptoms with deficiency. Prevention involves managing exposure and diet.

Area of Science:

  • Environmental Science
  • Toxicology
  • Nutritional Science

Background:

  • Selenium (Se) is a metalloid with critical roles as both a nutrient and a toxicant.
  • The narrow margin between adequate and excessive intake highlights its dual nature.
  • Pure selenium exists in various physical forms, but its biological effects are of primary concern.

Purpose of the Study:

  • To elucidate the risks associated with selenium (Se) toxicity, particularly selenosis.
  • To emphasize the diagnostic challenges due to overlapping symptoms of Se deficiency and toxicity.
  • To outline preventative strategies against Se toxicity.

Main Methods:

  • Literature review on selenium's properties, toxicity, and deficiency.
  • Analysis of common causes and manifestations of selenosis.
Keywords:
RuminantsSeleniumSelenosisToxicology

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  • Examination of diagnostic criteria and preventative measures for selenium toxicity.
  • Main Results:

    • Overuse of selenium supplements is the primary cause of selenosis.
    • Symptoms of Se toxicity often mimic those of Se deficiency, necessitating laboratory confirmation.
    • Effective prevention strategies include limiting exposure to seleniferous sources and managing dietary factors.

    Conclusions:

    • Selenium's dual role as nutrient and toxicant requires careful management of intake.
    • Accurate diagnosis of Se toxicity relies on laboratory testing to differentiate from deficiency.
    • Preventing selenosis involves controlling environmental and dietary exposure to selenium.