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The DNA replication fork suppresses CMG unloading from chromatin before termination.

Emily Low1, Gheorghe Chistol1, Manal S Zaher1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts 02115, USA.

Genes & Development
|September 18, 2020
PubMed
Summary

DNA suppresses CMG helicase ubiquitylation during replication. Upon fork convergence, this suppression is relieved, triggering CMG (Cdc45-MCM2-7-GINS) unloading from chromatin.

Keywords:
CMGCRL2Lrr1DNA replicationreplication terminationsingle-molecule imagingubiquitylation

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