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Updated: Jul 22, 2026

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
Published on: February 28, 2014
PathSTORM: a road to early cancer detection
Kris Troy1, Yang Liu2, Sarah J Hainer1
1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract:
Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.
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