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Updated: Dec 8, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

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HSP70 promotes MLKL polymerization and necroptosis

Andrea N Johnston1,2, Zhigao Wang2

  • 1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.

Molecular & Cellular Oncology
|September 18, 2020
PubMed
Summary

A new compound, necroptosis-blocking compound 1 (NBC1), inhibits necroptosis by targeting heat shock protein 70 (HSP70). This compound blocks HSP70, a key promoter of Mixed Lineage Kinase Domain-Like Protein (MLKL) activation and cell death.

Keywords:
HSP70MLKLNecroptosis✚-➔regulated cell death

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