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Published on: March 9, 2017
Leveraging synthetic chlorins for bio-imaging applications
Javier Hernández-Gil1, Jason S Lewis2, Thomas Reiner3
1Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. gonzalj4@mskcc.org and Biomedical MRI/MoSAIC, Department of Imaging and Pathology, Katholieke Universiteit Leuven, Herestraat 49, B3000, Leuven, Belgium.
Abstract:
Synthetic chlorins are not only fluorescent, the modulation of the tetrapyrrole system can also chelate metal ions. Conjugation of linkers at their pyrrolidines allows for conjugation to bio-molecules to create target specificity. By altering these chemo-photophysical properties, this work facilitates the use of chlorins in fluorescent imaging and positron emission tomography (PET).
