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Creating a Health Utility Value for Birdshot Chorioretinopathy
Anisha Sekaran1,2, Mohith Shamdas1,2, Robert J Barry1,2
1Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Ocular Immunology and Inflammation
|September 18, 2020
Summary
This study developed health utility values for birdshot chorioretinopathy (BCR) using Time Trade-Off (TTO) and Standard Gamble (SG) methods. Results indicate patient willingness to trade life years for improved vision, informing BCR management.
Area of Science:
- Ophthalmology
- Health Economics
- Patient-Reported Outcomes
Background:
- Birdshot chorioretinopathy (BCR) is a rare, chronic inflammatory eye disease impacting vision.
- Quantifying the health utility of BCR is crucial for treatment decisions and resource allocation.
Purpose of the Study:
- To establish health utility values for patients with birdshot chorioretinopathy using Time Trade-Off (TTO) and Standard Gamble (SG) methodologies.
- To assess the impact of BCR on patients' quality of life and their willingness to trade life for vision.
Main Methods:
- 28 adult BCR patients completed TTO, SG, EQ-5D-5L, and NEI VFQ-25 questionnaires.
- Clinical data including visual acuity were collected through detailed history and examination.
Main Results:
- Mean TTO utility was 0.90 and mean SG utility was 0.94.
- TTO utility demonstrated significant correlation with EQ-5D-5L index (p=.024) and NEI VFQ-25 composite score (p=.015).
- 11 patients (39%) would trade a mean of 5.4 years of life for perfect vision; 6 patients (22%) would accept a mean 28% risk of immediate death for perfect vision.
Conclusions:
- Health utility values derived from TTO and SG provide a quantitative measure of the burden of birdshot chorioretinopathy.
- Patient preferences highlight a significant desire for improved vision, even at the cost of life years or risk.
- These findings can inform clinical practice guidelines and health policy related to BCR management.
