The Subgrouping Structure of Newborns with Heterogenous Brain-Behavior Relationships
Yuanyuan Chen1, Shuxin Liu1,2, Andrew Salzwedel1
1Department of Biomedical Sciences and Imaging, Biomedical Imaging Research Institute (BIRI), Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Cerebral Cortex (New York, N.Y. : 1991)
|September 18, 2020
Summary
Newborn brain-behavior relationships show heterogeneity, impacting later intelligence quotient (IQ) development. Identifying these subgroups can lead to personalized developmental predictions.
Area of Science:
- Neuroscience
- Developmental Psychology
- Biostatistics
Background:
- Heterogeneity in infant brain and behavior is known.
- Limited research explores heterogeneity in brain-behavior relationships.
Purpose of the Study:
- Investigate relationship-level heterogeneity in newborns.
- Identify subgroups with distinct brain-behavior associations.
- Examine links to developmental outcomes.
Main Methods:
- Analyzed resting-state functional magnetic resonance imaging (fMRI) data from 81 infants.
- Assessed intelligence quotient (IQ) at 4 years.
- Delineated subgroups based on brain-behavior associations.
Main Results:
- Confirmed relationship-level heterogeneity in newborns.
- Identified two subgroups with similar brain connectivity but different brain-behavior links.
- Higher IQ subgroup showed congruent brain-behavior relationships; lower IQ subgroup did not.
Conclusions:
- Brain-behavior relationship heterogeneity exists in newborns.
- This heterogeneity influences developmental trajectories, specifically IQ.
- Findings support personalized, subgroup-specific predictive models for infant development.
