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Updated: Dec 8, 2025

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
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The potential mechanism of action of Sorcin and its interacting proteins

Jun Mao1, Fei Ling1, Jaceline Gislaine Pires Sanches1

  • 1Department of Pathology, Dalian Medical University, Dalian 116044, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 18, 2020
PubMed

Insights

Sorcin, a calcium-binding oncoprotein, is overexpressed in human tumors, contributing to multidrug resistance. This review details its biochemical functions and interactions, highlighting its role in cancer progression and potential therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Sorcin (Soluble resistance-related calcium binding protein) is a calcium-binding oncoprotein.
  • Overexpression of Sorcin in human tumors and cancer cell lines is linked to multidrug resistance (MDR).

Purpose of the Study:

  • To review the biochemical functions of Sorcin.
  • To explore Sorcin's interactions with other proteins and its role in biological processes.
  • To discuss future research prospects related to Sorcin's function in cancer.

Main Methods:

  • Literature review of Sorcin's biochemical functions.
  • Analysis of Sorcin's protein-protein interactions.
  • Summary of Sorcin's involvement in calcium homeostasis, apoptosis, and metastasis.

Main Results:

  • Sorcin modulates calcium homeostasis, apoptosis, and cancer metastasis.
  • Sorcin interacts with numerous proteins including p-glycoprotein, Annexin A7, and signal transducer and activator of transcription 3.
  • Sorcin's activity is implicated in multidrug resistance and cancer progression.

Conclusions:

  • Sorcin plays a significant role in various cellular processes relevant to cancer.
  • Understanding Sorcin's interactions provides insights into its function and potential as a therapeutic target.
  • Further research into Sorcin's activity may uncover new strategies for cancer treatment.
Keywords:
Interact proteinsMulti-drug resistanceOncoproteinSorcin

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