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Updated: Dec 8, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
The Gut Microbiota at the Service of Immunometabolism
Chloé Michaudel1, Harry Sokol2
1INRA, UMR1319 Micalis and AgroParisTech, Jouy en Josas, France; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.
Abstract:
The gut microbiota is implicated in immune system functions. Regulation of the metabolic processes occurring in immune cells is crucial for the maintenance of homeostasis and immunopathogenesis. Emerging data demonstrate that the gut microbiota is an actor in immunometabolism, notably through the effect of metabolites such as short-chain fatty acids, bile acids, and tryptophan metabolites. In this Perspective, we discuss the impact of the gut microbiota on the intracellular metabolism of the different subtypes of immune cells, including intestinal epithelial cells. Besides the effects on health, we discuss the potential consequences in infection context and inflammatory bowel diseases.
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