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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
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Relationships between mitral annular calcification and cardiovascular events: A meta-analysis
Tom Kai Ming Wang1, Brian P Griffin1, Bo Xu1
1Section of Cardiovascular Imaging, Heart and Vascular Institute Cleveland Clinic, Cleveland, OH, USA.
Echocardiography (Mount Kisco, N.Y.)
|September 19, 2020
Summary
Mitral annular calcification (MAC) is linked to increased risks of death and major cardiovascular events. This finding highlights MAC
Area of Science:
- Cardiology
- Gerontology
- Epidemiology
Background:
- Mitral annular calcification (MAC) is common in older adults.
- MAC is increasingly recognized for its links to cardiovascular disease risk and outcomes.
- Its impact on valvular heart disease and interventions is a focus of current research.
Purpose of the Study:
- To conduct a meta-analysis on the association between MAC and cardiovascular mortality and morbidity.
- To quantify the relationships between MAC and adverse cardiovascular events.
Main Methods:
- Searched PubMed, Cochrane, and Embase databases until November 30, 2019.
- Included 26 studies with 35,070 participants.
- Used random-effects models to pool data on MAC and cardiovascular outcomes.
Main Results:
- MAC was associated with significantly higher all-cause mortality (HR 1.76) and cardiovascular mortality (HR 1.85).
- MAC correlated with increased risks of myocardial infarction (HR 1.48), stroke (HR 1.51), heart failure (HR 1.55), and atrial fibrillation (HR 1.75).
- Patients with MAC had a higher likelihood of mitral valve replacement during cardiac surgery (OR 2.82).
Conclusions:
- Mitral annular calcification is associated with elevated rates of mortality and cardiovascular events.
- The prevalence of MAC has significant clinical implications for cardiovascular risk stratification.
- MAC presence warrants consideration in the management of valvular heart disease and interventions.
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