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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
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Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

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Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

247
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Related Experiment Video

Updated: Dec 8, 2025

Non-invasive Assessment of Microvascular and Endothelial Function
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FGF23 and Cardiovascular Risk.

Dominique Prié1

  • 1Faculté de santé de l'université de Paris, hôpital Necker Enfants Malades GHU Centre-Université de Paris AP-HP, INEM INSERM U1151, 149, rue de Sèvres 75015 Paris, France.

Annales D'Endocrinologie
|September 20, 2020
PubMed
Summary

Fibroblast growth factor 23 (FGF23) elevation in kidney disease contributes to cardiac issues. FGF23 may also be produced by heart cells as a stress response.

Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiology

Background:

  • Fibroblast growth factor 23 (FGF23) is a bone-derived hormone regulating phosphate and vitamin D metabolism.
  • In kidney disease, FGF23 levels rise due to impaired renal clearance.
  • FGF23 signaling in the heart, particularly its receptor FGFRs, is implicated in cardiac dysfunction.

Purpose of the Study:

  • To explore the role of FGF23 in cardiac pathophysiology, especially in the context of declining renal function.
  • To investigate the potential of FGF23 as a biomarker or therapeutic target in cardiovascular complications of kidney disease.

Main Methods:

  • Review of existing literature on FGF23, kidney disease, and cardiac function.
  • Analysis of FGF23's signaling pathways involving FGF receptors (FGFRs) and αKlotho.

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  • Examination of FGF23's effects on cardiomyocytes and cardiac structure.

    • Main Results:

    • Elevated FGF23 in renal decline activates FGFRs in cardiomyocytes, even without αKlotho.
    • This FGF23 signaling can lead to cardiac hypertrophy, altered contractility, and arrhythmias.
    • Cardiomyocytes themselves may produce FGF23, suggesting an adaptive response to cardiac stress.

    Conclusions:

    • High FGF23 levels in kidney disease pose a significant risk to cardiac health.
    • The therapeutic benefit of reducing FGF23 in dialysis patients remains unproven.
    • Endogenous FGF23 production by cardiomyocytes highlights its complex role in cardiac adaptation and pathology.