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A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats
Published on: November 6, 2019
Blowing up Neural Repair for Stroke Recovery: Preclinical and Clinical Trial Considerations
Nick S Ward1, S Thomas Carmichael2
1Department of Clinical and Motor Neuroscience, UCL Queen Square Institute of Neurology, London (N.S.W.).
Abstract:
The repair and recovery of the brain after stroke is a field that is emerging in its preclinical science and clinical trials. However, recent large, multicenter clinical trials have been negative, and conflicting results emerge on biological targets in preclinical studies. The coalescence of negative clinical translation and confusion in preclinical studies raises the suggestion that perhaps the field of stroke recovery faces a fate similar to stroke neuroprotection, with interesting science ultimately proving difficult to translate to the clinic. This review highlights improvements in 4 areas of the stroke neural repair field that should reorient the field toward successful clinical translation: improvements in rodent genetic models of stroke recovery, consideration of the biological target in stroke recovery, stratification in clinical trials, and the use of appropriate clinical trial end points.
Insights
Brain repair after stroke shows promise but faces translation challenges. This review suggests improvements in models, targets, and trial design for successful clinical translation of neural repair strategies.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Clinical Trials
Background:
- Stroke recovery research shows preclinical promise but faces challenges in clinical translation.
- Recent large clinical trials for stroke recovery have yielded negative results.
- Conflicting findings in preclinical studies complicate the identification of effective biological targets.
Purpose of the Study:
- To identify key areas for improvement in the field of stroke neural repair.
- To provide recommendations for reorienting research toward successful clinical translation.
- To address the gap between preclinical findings and clinical outcomes in stroke recovery.
Main Methods:
- Review of current preclinical and clinical research in stroke neural repair.
- Analysis of challenges in translating stroke recovery science.
- Identification of four critical areas for enhancing research and clinical trials.
Main Results:
- Improvements are needed in rodent genetic models for stroke recovery studies.
- Careful consideration of biological targets is crucial for stroke recovery interventions.
- Clinical trial stratification and appropriate endpoint selection are essential for success.
Conclusions:
- Reorienting the stroke neural repair field toward specific improvements can enhance clinical translation.
- Addressing issues in preclinical models, target identification, and clinical trial design is vital.
- Successful translation of stroke recovery science requires a strategic approach to research and testing.
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