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Biointerface engineering nanoplatforms for cancer-targeted drug delivery
Huaiyu Zhang1,2, Shujun Dong3, Zhongmin Li1,2
1Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Asian Journal of Pharmaceutical Sciences
|September 21, 2020
Summary
Biomembrane-camouflaged nanoplatforms offer superior cancer targeting for drug delivery. This review explores these advanced nanocarriers, detailing their development and potential in cancer therapy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Nanoparticle-based therapies are advancing cancer treatment.
- Selective drug delivery to tumors is crucial for efficacy.
- The tumor microenvironment presents unique challenges for drug delivery.
Purpose of the Study:
- To review biomimetic cell membrane-camouflaged nanoplatforms for cancer-targeted drug delivery.
- To classify these nanoplatforms based on their camouflage membranes.
- To discuss challenges and opportunities in this field.
Main Methods:
- Literature review of biomembrane-camouflaged nanoplatforms.
- Classification of nanocarriers by cell membrane origin.
- Analysis of biointerface engineering strategies.
Main Results:
- Biomembrane camouflage enhances cancer targeting capabilities.
- Various cell membranes (e.g., red blood cells, cancer cells) are utilized for camouflage.
- These nanoplatforms demonstrate potential for improved drug delivery.
Conclusions:
- Biomimetic nanoplatforms represent a promising strategy for targeted cancer therapy.
- Advanced biointerface engineering is key to optimizing these nanosystems.
- Further research is needed to address challenges and realize opportunities.

