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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

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Tumor microenvironment responsive drug delivery systems.

Qunye He1, Jun Chen1, Jianhua Yan1

  • 1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.

Asian Journal of Pharmaceutical Sciences
|September 21, 2020
PubMed
Summary
This summary is machine-generated.

Smart drug delivery systems (DDSs) respond to tumor environments for better targeting and release. This review covers DDSs triggered by tumor molecules, improving therapeutic efficiency.

Keywords:
Cancer therapyControlled releaseDrug delivery systemDynamic targetingStimuli responsive

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Conventional tumor-targeted drug delivery systems (DDSs) exhibit limitations including poor circulation, low targeting efficiency, inadequate tumor penetration, and uncontrolled drug release.
  • Tumor cellular molecule-triggered DDSs offer a promising solution to overcome these challenges by responding to the tumor microenvironment.

Purpose of the Study:

  • To review recent advancements in smart DDSs that are responsive to the tumor microenvironment for enhanced targeted drug delivery.
  • To summarize dynamic targeting strategies and functional moieties sensitive to various tumor cellular stimuli.

Main Methods:

  • Review of current literature on stimuli-responsive DDSs.
  • Analysis of DDS properties (size, charge, ligand exposure) in response to tumor microenvironments.
  • Summarization of functional moieties sensitive to pH, glutathione, adenosine-triphosphate, reactive oxygen species, enzymes, and inflammatory factors.

Main Results:

  • Smart DDSs can dynamically alter properties to improve tumor targeting and achieve controlled drug release.
  • Various stimuli-responsive mechanisms, drug loading models, and their respective merits and drawbacks have been identified.
  • Several examples of multi-stimuli responsive DDSs are presented, highlighting their potential.

Conclusions:

  • Smart tumor environment-responsive DDSs represent a significant advancement in targeted drug delivery.
  • Further research into multi-stimuli responsive systems and addressing current challenges is crucial for optimizing therapeutic efficiency.