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Updated: Dec 8, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
The obesity paradox and diabetes
Giovanni Gravina1, Federica Ferrari2, Grazia Nebbiai3
1Center for Eating Behaviour and Metabolism Disorders, Casa di Cura San Rossore, Pisa, Italy. gravina@sanrossorecura.it.
The "obesity paradox" suggests overweight individuals with type 2 diabetes mellitus (T2DM) may have better outcomes. However, research limitations mean weight management guidelines for T2DM remain crucial.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Public Health
Background:
- Obesity is a known risk factor for type 2 diabetes mellitus (T2DM).
- Some studies indicate an
Purpose of the Study:
- To provide a narrative overview of the relationship between obesity and T2DM.
- To specifically examine the
Main Methods:
- Comprehensive literature search of major databases (MEDLINE/PubMed, CINAHL, EMBASE, Cochrane Library) up to March 2020.
- Selection of 30 relevant studies investigating obesity, clinical outcomes, and mortality in T2DM patients.
Main Results:
- Many studies report a potential
Conclusions:
- Data on the obesity paradox in T2DM are conflicting due to study limitations.
- Established guidelines recommending diet and physical activity are essential for managing overweight/obese T2DM patients.
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