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Updated: Dec 8, 2025
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Published on: August 22, 2017
10.3K
Translational control in aging and neurodegeneration
Geena Skariah1, Peter K Todd1,2
1Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Wiley Interdisciplinary Reviews. RNA
|September 21, 2020
Summary
Aging impairs protein synthesis, impacting neurodegeneration. New research reveals how translation regulation changes with age, offering therapeutic targets for age-related diseases and extending lifespan by balancing protein synthesis and breakdown.
Area of Science:
- Molecular Biology
- Gerontology
- Neuroscience
Background:
- Protein metabolism is crucial for aging and neurodegeneration.
- While protein degradation in aging is well-studied, protein synthesis alterations are less understood.
- Aging affects the protein synthetic machinery and translation regulatory factors.
Purpose of the Study:
- To review the role of translation regulation in aging.
- To focus on factors involved in age-related neurodegeneration.
- To discuss how new technologies illuminate age-dependent translation changes.
Main Methods:
- Review of existing literature on translation regulation and aging.
- Discussion of emerging technologies like ribosome profiling and mass spectrometry.
- Analysis of age-dependent, mRNA-specific translation rate changes.
Main Results:
- Aging alters protein synthesis machinery and regulatory factors.
- Lifespan-extending interventions often decrease protein synthesis rates.
- New technologies reveal interplay between anabolic and catabolic pathways in aging.
Conclusions:
- Translation regulation plays a critical role in aging and neurodegeneration.
- Age-related changes in translation contribute to functional decline.
- Posttranscriptional gene regulation offers therapeutic targets for aging and neurodegeneration.
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