Related Experiment Video
Updated: Dec 8, 2025
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.6K
Factors Associated with Functional Capacity in CKD Patients
Emanuele Poliana Lawall Gravina1, Bruno Valle Pinheiro1,2, Luciana Angélica da Silva Jesus1
1Pulmonary and Critical Care Division, University Hospital of Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Clinical Nursing Research
|September 22, 2020
Summary
Functional capacity in chronic kidney disease (CKD) patients is linked to age, income, and CKD stage. Maintaining physical function requires addressing these factors to improve quality of life.
Area of Science:
- Nephrology
- Gerontology
- Rehabilitation Medicine
Background:
- Chronic kidney disease (CKD) significantly impacts patients' physical function and quality of life.
- Assessing functional capacity is crucial for managing CKD progression and patient outcomes.
Purpose of the Study:
- To identify key factors associated with functional capacity in patients diagnosed with chronic kidney disease.
- To understand the relationship between demographic, clinical, and quality of life variables and physical function in CKD patients.
Main Methods:
- Patients underwent the six-minute walk test (6MWT), 10-repetition sit-to-stand test (STS-10), and SF-36 health-related quality of life questionnaire (HRQoL).
- Statistical analyses, including multiple linear regression, were employed to determine significant associations.
Main Results:
- Higher functional capacity (≥80% on 6MWT) correlated with higher education, income, BMI, eGFR, and lower age and STS-10 time.
- Gender, age, family income, CKD stage, STS-10 time, and the physical component of HRQoL were significantly associated with 6MWT distance.
Conclusions:
- CKD progression demonstrably decreases functional capacity in affected patients.
- Interventions targeting modifiable factors like age, income, and physical performance may help preserve functional capacity in CKD patients.
Related Concept Videos
01:17Factors Affecting Renal Clearance: Renal Impairment
304
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
304
01:25Chronic Kidney Disease I: Introduction
398
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
398
01:28Chronic Kidney Disease III: Interprofessional Care
243
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
243
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
91
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
91
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
159
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
159
01:24Chronic Kidney Disease II: Clinical Manifestations
403
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
403