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Updated: Dec 8, 2025

Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
Published on: November 8, 2017
Oxygen transport in a permeable model of abdominal aortic aneurysm
Rana Zakerzadeh1, Tanja Cupac1, Michael Durka2
1Department of Biomedical Engineering, Rangos School of Health Sciences, Duquesne University, Pittsburgh, PA, USA.
Abstract:
This paper reports on modelling and simulation of the coupled mass and momentum transport through the arterial lumen and the porous arterial wall of an abdominal aortic aneurysm (AAA). The effect of porous structure and intramural flow, which is usually neglected, is essential to quantify the oxygen concentration in the aneurysmal wall and will be addressed in this work via a novel coupled fluid-porous structure-mass transport model for AAA. The computational solver provides a prediction of the filtration velocity and oxygen concentration in the artery and further simulations are used to investigate the relation between the wall oxygen concentration and permeability. The results demonstrate the essential coupling between blood and filtration flow and specifically how their interactions affect oxygen transport.
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