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Hospital-based Buprenorphine Micro-dose Initiation
Melissa B Weimer1, Michael Guerra, Gina Morrow
1Department of Internal Medicine, Program in Addiction Medicine, Yale School of Medicine, New Haven, CT (MBW), Yale New Haven Hospital, New Haven, CT (MG, GM), University of Connecticut Mansfield, CT (KA).
Journal of Addiction Medicine
|September 22, 2020
Summary
Initiating buprenorphine treatment in hospitals can be difficult. This study introduces a new low-dose hospital strategy to help patients switch from full opioid agonists to buprenorphine, avoiding precipitated withdrawal.
Area of Science:
- Addiction Medicine
- Pharmacology
- Hospital Administration
Background:
- Buprenorphine induction is challenging for patients with chronic pain or those unable to stop opioids, risking precipitated withdrawal.
- Existing low-dose outpatient buprenorphine induction strategies are not suitable for hospital settings due to regulatory differences.
- Hospital-based opioid use disorder treatment requires adaptable induction protocols.
Purpose of the Study:
- To present a novel, low-dose buprenorphine initiation strategy specifically designed for the hospital setting.
- To overcome barriers associated with transitioning patients from full opioid agonists to buprenorphine within a hospital environment.
- To provide a generalizable model for hospital-based buprenorphine induction.
Main Methods:
- Development of a novel low-dose buprenorphine induction protocol for inpatient use.
- Implementation of the protocol to facilitate the transition from full opioid agonists.
- Monitoring patient response and adherence to the new strategy.
Main Results:
- The novel strategy successfully facilitated buprenorphine initiation in a hospital setting.
- Patients were able to transition from full opioid agonists to buprenorphine without significant precipitated withdrawal.
- The protocol demonstrated feasibility within hospital medication regulations.
Conclusions:
- A low-dose, hospital-based buprenorphine initiation strategy can effectively manage patients transitioning from full opioid agonists.
- This novel approach addresses challenges in hospital settings, improving treatment accessibility.
- Further research should validate this strategy across diverse hospital populations and settings.
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