A new sesquiterpene from mangrove endophytic fungus Aspergillus sp. GXNU-MA1
Dexiong Zhou1, Wenxiu Zhang1, Lili Hao1
1State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, P. R. China.
Abstract:
A new sesquiterpene, gxsespene A (1), and four known sesquiterpene derivatives 2-5 were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-MA1. Their structures were elucidated based on high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of 1 was established. Compounds 1-5 were evaluated for their anti-inflammatory activities against the nitric oxide (NO) production, and compounds 1-5 showed moderate inhibitory activities with IC50 values ranging from 16.15 to 27.08 µM.
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