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Updated: Dec 8, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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A significant decrease in hemoglobin concentrations may predict occurrence of necrotizing enterocolitis in preterm

Na Cai1, Wenting Fan1, Min Tao1

  • 1Department of Pediatrics, The First Hospital Affiliated to Army Medical University, Chongqing, China.

The Journal of International Medical Research
|September 23, 2020
PubMed
Summary
This summary is machine-generated.

A significant drop in hemoglobin concentration (HC) in preterm infants with sepsis can predict necrotizing enterocolitis (NEC). This finding highlights HC decrease as a key indicator for early NEC detection in vulnerable newborns.

Keywords:
Premature infanthemoglobin concentrationnecrotizing enterocolitisred blood cell transfusionsepsisventilator

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Area of Science:

  • Neonatalogy
  • Pediatric critical care
  • Hematology

Background:

  • Necrotizing enterocolitis (NEC) is a serious condition affecting preterm infants.
  • Late-onset sepsis is a common complication in premature neonates.
  • Predictive markers for NEC in septic preterm infants are crucial for timely intervention.

Purpose of the Study:

  • To evaluate the clinical significance of decreased hemoglobin concentration (HC) in predicting NEC.
  • To assess the association between HC reduction and NEC occurrence in preterm infants with late-onset sepsis.

Main Methods:

  • Retrospective cohort study (January 2015 - January 2020).
  • Inclusion of preterm neonates (gestational age <37 weeks) with late-onset sepsis (>3 days).
  • Categorization into non-decrease, mild decrease, and severe decrease HC groups for comparison.

Main Results:

  • Eighty infants were studied; higher mortality and NEC incidence in the severe HC decrease group.
  • Significant differences in HC decrease, red blood cell transfusion, and ventilator use between NEC and non-NEC groups.
  • A significant decrease in HC was identified as an independent risk factor for NEC.

Conclusions:

  • Significant hemoglobin concentration decrease is an independent risk factor for NEC in preterm infants with sepsis.
  • Monitoring HC changes can aid in predicting NEC development in this high-risk population.