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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

Updated: Dec 8, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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CASC15: A Tumor-Associated Long Non-Coding RNA.

Bei Wang1, Wen Xu1, Yuxuan Cai1

  • 1College of Medical Science, China Three Gorges University, Yichang443002, China.

Current Pharmaceutical Design
|September 23, 2020
PubMed
Summary
This summary is machine-generated.

Long non-coding RNA CASC15 (lncRNA CASC15) plays a role in tumor development. This lncRNA is linked to various cancers, offering potential as a therapeutic target.

Keywords:
CASC15Long non-coding RNAbiomarkermalignancymolecular mechanismtherapeutic target

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Area of Science:

  • Oncology
  • Molecular Biology
  • RNA Research

Background:

  • Long non-coding RNA CASC15 (lncRNA CASC15) is implicated in numerous tumor biological processes.
  • It is recognized as a potential novel therapeutic target in oncology.

Purpose of the Study:

  • To elucidate the pathophysiological function of CASC15 in diverse tumor types.
  • To summarize the specific pathophysiological mechanisms of CASC15 in cancer development.

Main Methods:

  • Comprehensive literature review on CASC15 and its relationship with various tumors.
  • Analysis and summarization of existing research on CASC15's pathophysiological mechanisms.

Main Results:

  • Abnormal expression of lncRNA CASC15 is observed in numerous cancers, including breast, lung, and gastric cancers.
  • CASC15 is upregulated in most tumors but downregulated in ovarian cancer, glioma, and neuroblastoma.
  • CASC15 influences tumor cell proliferation, invasion, and apoptosis.

Conclusions:

  • LncRNA CASC15 demonstrates significant potential as a therapeutic target or diagnostic marker for multiple types of cancer.
  • Further research into CASC15's role could lead to novel cancer treatment strategies.