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Published on: April 10, 2018
CASC15: A Tumor-Associated Long Non-Coding RNA
Bei Wang1, Wen Xu1, Yuxuan Cai1
1College of Medical Science, China Three Gorges University, Yichang443002, China.
Background:
CASC15, one of long non-coding RNA, is involved in the regulation of many tumor biological processes, and is expected to become a new biological therapeutic target. This paper aims to elucidate the pathophysiological function of CASC15 in various tumors.
Methods:
The relationship between CASC15 and tumors was analyzed by searching references, and summarized the specific pathophysiological mechanism of CASC15.
Results:
LncRNA CASC15 is closely related to tumor development, and has been shown to be abnormally high expressed in all kinds of tumors, including breast cancer, cervical cancer, lung cancer, hepatocellular carcinoma, gastric cancer, bladder cancer, colon cancer, colorectal cancer, cardiac hypertrophy, intrahepatic cholangiocarcinoma, leukemia, melanoma, tongue squamous cell carcinoma and nasopharyngeal carcinoma. However, CASC15 has been found to be down-expressed abnormally in ovarian cancer, glioma and neuroblastoma. Besides, it is identified that CASC15 can affect the proliferation, invasion and apoptosis of tumors.
Conclusion:
LncRNA CASC15 has the potential to become a new therapeutic target or marker for a variety of tumors.
Insights
Long non-coding RNA CASC15 (lncRNA CASC15) plays a role in tumor development. This lncRNA is linked to various cancers, offering potential as a therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- RNA Research
Background:
- Long non-coding RNA CASC15 (lncRNA CASC15) is implicated in numerous tumor biological processes.
- It is recognized as a potential novel therapeutic target in oncology.
Purpose of the Study:
- To elucidate the pathophysiological function of CASC15 in diverse tumor types.
- To summarize the specific pathophysiological mechanisms of CASC15 in cancer development.
Main Methods:
- Comprehensive literature review on CASC15 and its relationship with various tumors.
- Analysis and summarization of existing research on CASC15's pathophysiological mechanisms.
Main Results:
- Abnormal expression of lncRNA CASC15 is observed in numerous cancers, including breast, lung, and gastric cancers.
- CASC15 is upregulated in most tumors but downregulated in ovarian cancer, glioma, and neuroblastoma.
- CASC15 influences tumor cell proliferation, invasion, and apoptosis.
Conclusions:
- LncRNA CASC15 demonstrates significant potential as a therapeutic target or diagnostic marker for multiple types of cancer.
- Further research into CASC15's role could lead to novel cancer treatment strategies.
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