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Related Concept Videos

Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

959
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
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Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

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Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
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Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

2.4K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

2.9K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
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Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

2.1K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
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Related Experiment Video

Updated: Dec 8, 2025

The Preparation and Properties of Thermo-reversibly Cross-linked Rubber Via Diels-Alder Chemistry
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The Preparation and Properties of Thermo-reversibly Cross-linked Rubber Via Diels-Alder Chemistry

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Chelation Crosslinking of Biodegradable Elastomers.

Ying Chen1, Paula G Miller1, Xiaochu Ding1

  • 1Meinig School of Biomedical Engineering, College of Engineering, Cornell University, 277 Kimball Hall, 134 Hollister Drive, Ithaca, NY, 14853, USA.

Advanced Materials (Deerfield Beach, Fla.)
|September 23, 2020
PubMed
Summary

Chelation creates novel biodegradable elastomers using metal ions to tune properties. These new biomaterials show excellent tissue compatibility, offering advanced applications in medicine.

Keywords:
biocompatibilitybiodegradable elastomersmetal chelation crosslinking

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials Engineering

Background:

  • Elastomers are network polymers, typically crosslinked by strong covalent bonds, which can limit their applications.
  • Weakly crosslinked elastomers show increased plastic deformation, but controlled degradation and tunable properties remain challenging.
  • Chelation offers a novel crosslinking mechanism for designing advanced polymer networks.

Purpose of the Study:

  • To report chelation as a mechanism for producing biodegradable elastomers.
  • To investigate the tunability of elastomer properties through metal ion coordination.
  • To evaluate the biocompatibility of chelation-crosslinked elastomers in a murine model.

Main Methods:

  • Synthesis of a block copolymer via polycondensation of sebacic acid, 1,3-propanediol, and a Schiff-base ligand.
  • Crosslinking of the block copolymer using biologically relevant metal ions (e.g., Fe3+).
  • Characterization of elastomer properties and assessment of biocompatibility in subcutaneous implantation studies in mice.

Main Results:

  • Chelation-crosslinked elastomers exhibit tunable mechanical properties based on metal ion type, concentration, and ligand density.
  • Iron(III) (Fe3+) crosslinked elastomers demonstrated superior subcutaneous tissue compatibility compared to polycaprolactone.
  • Implanted materials degraded with minimal fibrosis, allowing restoration of native tissue architecture.

Conclusions:

  • Chelation provides a versatile platform for designing biodegradable elastomers with tunable properties.
  • These novel elastomers show promising biocompatibility for biomedical applications.
  • The chelation approach opens new avenues for advanced materials in medicine and beyond.