[; THE ATHEROGENIC IMPACT OF ORAL CAVITY DISBIOSIS (REVIEW)]

Area of Science:

• Cardiovascular Research
• Microbiome Research
• Immunology

Background:

• Oral cavity dysbiosis is increasingly recognized as a contributing factor to cardiovascular disease (CVD).
• The link between oral microbiome imbalance and atherosclerosis initiation and destabilization requires further elucidation.
• Understanding these connections is crucial for developing targeted preventative strategies.

Purpose of the Study:

• To review the atherogenic impact of oral cavity dysbiosis.
• To explore the pathophysiological and pathoimmunobiochemical mechanisms linking oral dysbiosis to atherosclerosis.
• To highlight the role of oral microbiome dysbiosis as a contemporary risk factor for CVD.

Main Methods:

• Literature review synthesizing current research on oral microbiome dysbiosis and atherosclerosis.
• Analysis of pathophysiological pathways involved in atheroma formation and destabilization.
• Examination of immunobiochemical aspects connecting oral health to cardiovascular health.

Main Results:

• Oral dysbiosis contributes to atherosclerosis initiation and atheroma destabilization through specific mechanisms.
• The oral microbiome plays a revolutionary role in the development and progression of CVD.
• Identifying these links provides a foundation for improved cardio- and vasoprotection.

Conclusions:

• Oral cavity dysbiosis is a significant and contemporary risk factor for cardiovascular disease.
• Elucidating the mechanisms of oral dysbiosis in CVD pathogenesis is key to effective prevention.
• Targeted cardio- and vasoprotection strategies informed by oral health can improve patient prognosis and quality of life.