THE MOLECULAR MECHANISM OF DIABETES MELLITUS - RELATED IMPAIRMENT OF CARDIOVASCULAR HOMEOSTASIS (REVIEW)

Area of Science:

• Endocrinology
• Cardiology
• Diabetology

Background:

• Diabetes mellitus is a growing global health concern, particularly affecting younger populations.
• Industrialization contributes to the rising incidence of this endocrine disorder.
• Diabetes triggers detrimental cycles impacting cardiovascular homeostasis.

Purpose of the Study:

• To elucidate the pathophysiological mechanisms of diabetes-induced cardiovascular impairment.
• To identify molecular pathways underlying cardiovascular complications in diabetes.
• To drive advancements in diabetology and pharmacological interventions.

Main Methods:

• The study focuses on understanding the molecular mechanisms of cardiovascular system damage in diabetes.
• It involves analyzing the pathophysiological processes and remodeling dynamics in the diabetic continuum.
• Research aims to identify molecular targets for therapeutic intervention.

Main Results:

• Diabetes mellitus is an independent risk factor for cardiovascular comorbidities.
• Micro- and macroangiopathies (angio-, neuro-, nephropathy) are common adverse outcomes.
• Vision impairment due to angiopathy predicts cardiovascular pathology onset or exacerbation.

Conclusions:

• A deeper understanding of diabetes-driven cardiovascular impairment is fundamentally relevant.
• Research in this area will facilitate the development of novel pharmacological treatments.
• Improved treatments can enhance the quality of life and prognosis for diabetic patients.