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Granulomatous lung disease in children by aspiration of medications
Insights
Post-mortem examinations revealed orally administered drugs, including cholestyramine and phenobarbital, as foreign bodies in infant lungs. These findings highlight aspiration as a cause of pseudomiliary granulomatous lesions in children.
Area of Science:
- Pediatric Pathology
- Toxicology
- Histopathology
Background:
- Investigating foreign body aspiration in pediatric autopsies.
- Understanding the pathological effects of orally administered medications in infants.
Observation:
- Post-mortem examinations of 8 infants and one child revealed drug particles (cholestyramine, phenobarbital, phenydantin) in lung tissue.
- Microscopic examination detailed changes caused by these deposits and presented histological identification methods.
Findings:
- Drug deposits in the lungs were identified as foreign bodies.
- Aspiration was implicated in the formation of these deposits, leading to pseudomiliary granulomatous changes.
Implications:
- Proposes a distinct classification for these drug-induced aspiratory lesions in children.
- Emphasizes the importance of considering iatrogenic causes in pediatric lung pathology.
- Highlights the need for awareness among clinicians and pathologists regarding potential drug aspiration in infants.
Abstract:
Post mortem examinations of 8 infants, 11 d to 5 months old and one 12 year old girl, demonstrated foreign bodies in the lungs which could be identified as orally administered drugs: cholestyramine (Questran) and phenobarbital (Luminal, Gardenal) or phenydantin-components. The microscopic changes caused by such deposits and the histologic methods of identifying medicines are presented. The authors point to the role of aspiration in deposit formation and to the pseudomiliary granulomatous nature of subsequent changes. It is proposed to define the alterations as a separate form of aspiratory lesion in children.