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Updated: Dec 8, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Recent progress of 1,1-difunctionalization of olefins
Shuang Yang1, Yuhang Chen1, Zhenhua Ding1
1Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China. zhding@cpu.edu.cn.
Abstract:
Olefins are a very important class of compounds and broadly used in the construction of various synthetic building blocks and practical industrial production. The difunctionalization of olefins provides one of the most powerful methods for the C-C or C-X bond formation with a rapid increase of the molecular complexity and synthetic value economically and effectively. Compared with the vigorous growth and abundant achievements of 1,2-difunctionalization of olefins, 1,1-difunctionalization is a relatively emerging and inadequately exploited research direction, despite being tremendously attractive from synthetic perspectives. In this minireview, we provide a brief overview of the advancements of 1,1-difunctionalization of olefins in the past twenty years, and prospects of future developments.
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