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Updated: Dec 8, 2025

Influenza A Virus Studies in a Mouse Model of Infection

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

Animal models for COVID-19.

César Muñoz-Fontela^1,2, William E Dowling³, Simon G P Funnell⁴

¹Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

|September 23, 2020

Summary

This summary is machine-generated.

Animal models are crucial for developing vaccines and therapies against COVID-19. This summary reviews current findings and information for preclinical testing of potential treatments for SARS-CoV-2.

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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

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Last Updated: Dec 8, 2025

Influenza A Virus Studies in a Mouse Model of Infection

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses

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Published on: January 20, 2017

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Area of Science:

Virology
Immunology
Epidemiology

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic, emerging in late 2019.
The virus has spread globally, causing millions of infections and deaths.
Lack of pre-existing human immunity necessitates rapid development of medical countermeasures.

Purpose of the Study:

To summarize findings on animal models for COVID-19.
To provide information for preclinical testing of vaccine and therapeutic candidates.

Main Methods:

Review of existing research and data on animal models for SARS-CoV-2.
Information compilation for preclinical evaluation standards.

Main Results:

Animal models are essential for accelerating the testing of vaccines and therapeutics.
Established models aid in understanding SARS-CoV-2 pathogenesis and immune responses.
Data supports the use of specific animal models for evaluating vaccine efficacy and therapeutic potential.

Conclusions:

Animal models play a critical role in the fight against the COVID-19 pandemic.
Standardized preclinical testing in animal models is vital for regulatory approval of new treatments.
Continued research and refinement of animal models are necessary to combat SARS-CoV-2 and future viral threats.