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Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease.

Molly Easter1, Seth Bollenbecker1, Jarrod W Barnes1,2

  • 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Aging accelerates chronic obstructive pulmonary disease (COPD) through cellular aging pathways. This review explores aging

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Area of Science:

  • Pulmonary Medicine
  • Gerontology
  • Molecular Biology

Background:

  • Chronic obstructive pulmonary disease (COPD) is a global health crisis and the third leading cause of death.
  • COPD involves chronic airway inflammation, loss of lung function, and alveolar-capillary damage.
  • Key risk factors for COPD include cigarette smoking and the aging process.

Purpose of the Study:

  • To review the role of aging and age-associated signaling pathways in COPD pathogenesis.
  • To examine the impact of aging on current COPD treatment strategies.
  • To discuss novel therapeutic approaches for COPD, including senolytic and anti-aging therapies.

Main Methods:

  • Literature review of current scientific publications.
  • Analysis of aging pathways implicated in COPD.
  • Evaluation of established and experimental COPD treatments.

Main Results:

  • Aging pathways like telomere attrition, epigenetic alterations, and cellular senescence contribute to COPD.
  • These aging mechanisms exacerbate COPD progression and impair lung function.
  • Senolytic and anti-aging therapies show potential for novel COPD treatment.

Conclusions:

  • Aging is a critical factor in COPD development and progression.
  • Targeting age-related pathways offers promising new avenues for COPD management.
  • Senolytic and anti-aging interventions represent a potential paradigm shift in treating COPD.