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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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COVID-19 Infection and High Intracoronary Thrombus Burden

Ali Kirresh1, Gerry Coghlan1, Luciano Candilio1

  • 1Cardiology Department, Royal Free Hospital, London, United Kingdom.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|September 24, 2020
PubMed

Insights

This study reports the first case of COVID-19 associated with ST-elevation myocardial infarction (STEMI), highlighting a high thrombus burden. Understanding this link is crucial for managing severe coronavirus disease patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Thrombosis

Background:

  • Coronavirus 2019 (COVID-19) is a global pandemic with emerging evidence linking it to a pro-thrombotic state.
  • ST-segment elevation myocardial infarction (STEMI) is a severe form of heart attack.

Observation:

  • The first reported patient with COVID-19 presented with an inferior STEMI.
  • This patient exhibited a significant intracoronary thrombus burden.

Findings:

  • The high thrombus burden in COVID-19 associated STEMI may be linked to cytokine storm, endothelial dysfunction, plaque rupture, and hypercoagulability.
  • This case underscores a potential mechanism for acute cardiovascular events in COVID-19 patients.

Implications:

  • Further research is needed to elucidate the pro-thrombotic mechanisms in COVID-19.
  • Clinical management strategies for COVID-19 patients may need to consider thrombotic risk stratification and anticoagulation.
  • This finding has implications for understanding and treating cardiovascular complications during pandemics.

Keywords:
COVID-19Coronary thrombusMyocardial infarction

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