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Related Experiment Videos

Fluorinated corticosteroid toxicity in infants.

P E Romano, H S Traisman, O C Green

    American Journal of Ophthalmology
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    A child died from Cushing's syndrome caused by topical fluorinated corticosteroids used after corneal surgery for sclerocornea. This highlights the risks of prolonged steroid use in pediatric ophthalmology.

    Area of Science:

    • Ophthalmology
    • Endocrinology
    • Pediatric Medicine

    Background:

    • Sclerocornea is a rare congenital condition requiring corneal grafts.
    • Corticosteroids are frequently used post-keratoplasty to prevent graft rejection.
    • Fluorinated corticosteroids offer potent anti-inflammatory effects but carry significant side effect risks.

    Observation:

    • An 11-month-old infant developed Cushing's syndrome.
    • The syndrome was attributed to routine topical and periocular administration of fluorinated corticosteroids.
    • These medications were prescribed following corneal homografts for sclerocornea.

    Findings:

    • The infant's Cushing's syndrome, a result of exogenous steroid exposure, led to fatal complications.
    • This case underscores the potential for systemic absorption and adverse effects from topical ophthalmic steroids, even in infants.

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    Implications:

    • Careful monitoring for systemic side effects is crucial in infants receiving long-term topical corticosteroids.
    • Alternative immunosuppressive strategies may be considered to minimize steroid-related morbidity.
    • This case emphasizes the need for judicious use and dose optimization of fluorinated corticosteroids in pediatric ophthalmology.