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Ornithine and breast cancer: a matched case-control study
Jiayi Zhang1, Baihui Tao2, Yiran Chong2
1Department of Ultrasonography, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Scientific Reports
|September 24, 2020
Summary
Higher levels of the amino acid ornithine may lower breast cancer risk in women. This study found a 12% reduction in risk for each standard deviation increase in ornithine. Further research is warranted.
Area of Science:
- Biochemistry
- Oncology
- Human Physiology
Background:
- Ornithine and its metabolites are implicated in tumor development.
- The relationship between ornithine and human breast cancer remains uncertain.
Purpose of the Study:
- To investigate the association between circulating ornithine levels and breast cancer risk in females.
Main Methods:
- A 1:1 age-matched case-control study involving 735 female breast cancer cases and 735 controls.
- Ornithine levels were measured in fasting blood samples.
- Breast cancer diagnosis and control ascertainment were confirmed via pathological testing and clinical examinations.
Main Results:
- Each standard deviation increase in ornithine levels was associated with a 12% reduction in breast cancer risk (adjusted OR 0.88; 95% CI 0.79-0.97).
- No significant differences in the association were observed across pathological stages, tumor grades, or molecular subtypes.
Conclusions:
- Elevated circulating ornithine levels are linked to a reduced risk of breast cancer in women.
- Ornithine may play a protective role in breast cancer development.
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