Ondine's curse and the anaesthetist

Area of Science:

• Pediatric Anesthesiology
• Respiratory Medicine
• Neurology

Background:

• Central hypoventilation syndrome (CHS), or Ondine's curse, is a rare but serious condition affecting autonomic control of breathing.
• It necessitates specialized awareness due to its potential impact on respiratory function, particularly during anesthesia and critical care.

Purpose of the Study:

• To review the clinical features of central hypoventilation syndrome.
• To discuss the treatment and management strategies for Ondine's curse.
• To highlight the importance of awareness among anesthesiologists in pediatric and intensive care settings.

Main Methods:

• Literature review of central hypoventilation syndrome.
• Discussion of clinical presentations and diagnostic criteria.
• Overview of current therapeutic and supportive management approaches.

Main Results:

• Central hypoventilation syndrome is characterized by impaired ventilatory response to hypercapnia and hypoxia.
• Management requires a multidisciplinary approach, often involving ventilatory support.
• Early recognition and intervention are crucial for improving outcomes.

Conclusions:

• Central hypoventilation syndrome poses significant anesthetic risks.
• Anesthesiologists in pediatric and intensive care units must be prepared to manage patients with Ondine's curse.
• Increased awareness and understanding can lead to better patient safety and care.