The role of mast cell-derived mediators in airway function

The airway mast cell appears to play an important role in a number of pathophysiologic responses. Mast cells may be activated directly (e.g., by specific antigen) or indirectly (e.g., by an epithelial cell product such as 15-HETE). When activated, the mast cell releases mediators that may have direct effects or indirect effects. Mast cells and mediators undoubtedly play a role in specific airway responses. The data presented here are intended to serve only as examples of the complex way in which various cells and inflammatory mediators may interact to produce a physiologic response in the airways. Possibilities exist for numerous interactions between additional mediators as well as additional cell types. Because of the complexity of the system, characterization of activation and secretion by isolated pure cells, and studies of cell-to-cell interactions in vitro appear to be important first steps toward understanding the even more complex interactions that occur in vivo.