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Present expectations in cardiac transplantation.

W A Baumgartner, S Augustine, A M Borkon

    The Annals of Thoracic Surgery
    |June 1, 1987
    PubMed
    Summary
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    Cyclosporine has improved cardiac transplantation outcomes, with high survival and rehabilitation rates. While side effects like renal dysfunction occur, long-term quality of life is significantly enhanced for transplant recipients.

    Area of Science:

    • Cardiology
    • Immunosuppression

    Background:

    • Cyclosporine's introduction has boosted enthusiasm for cardiac transplantation.
    • Orthotopic cardiac transplantation is increasingly utilized for various heart conditions.

    Purpose of the Study:

    • To evaluate the outcomes of cardiac transplantation using cyclosporine-based immunosuppression.
    • To assess patient survival, rehabilitation, and side effects associated with cyclosporine.

    Main Methods:

    • Retrospective analysis of 61 cardiac transplant recipients from July 1983.
    • Maintenance immunosuppression primarily involved prednisone and cyclosporine.
    • Tracking of rejection incidence, infection rates, and major side effects.

    Main Results:

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  • Actuarial survival rates at 1 and 2 years were 84% and 76%, respectively.
  • Major cyclosporine side effects included renal dysfunction (63%) and hypertension (61%).
  • 96% of recipients were rehabilitated, with 50% returning to work.

    • Conclusions:

    • Cardiac transplantation with cyclosporine offers extended life and high rehabilitation rates.
    • Careful management of cyclosporine's side effects is crucial for long-term success.
    • Cyclosporine has significantly improved the outlook for cardiac transplant recipients.