Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

606
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
606
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

405
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
405
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

634
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
634
Decreased Body Temperature01:29

Decreased Body Temperature

861
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
861
Aging01:26

Aging

477
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
477
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function.

Aging cell·2026
Same author

Operationalizing AD Biomarker Return of Research Results: Methods from the KU ADRC.

Biopreservation and biobanking·2026
Same author

<i>APOE4</i> Drives Sex- and Diet-Dependent Effects on AD-Like Pathology, Cognition, and Mitochondrial Function.

FASEB bioAdvances·2026
Same author

Limbic-predominant neuroimaging correlates of plasma p-Tau217 in preclinical and clinical Alzheimer's disease.

Frontiers in aging neuroscience·2026
Same author

Larger baseline body stature predicts one-year amyloid change in cognitively normal older adults enriched with elevated amyloid status.

Journal of Alzheimer's disease : JAD·2026
Same author

Reimagining Care Delivery for Alzheimer Disease.

JAMA neurology·2026

Related Experiment Video

Updated: Dec 8, 2025

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.3K

Heat therapy: possible benefits for cognitive function and the aging brain.

Alex T Von Schulze1, Fengyan Deng1, Jill K Morris2

  • 1Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, Kansas.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 24, 2020
PubMed
Summary

Heat therapy may offer a novel treatment for Alzheimer's disease (AD) by improving whole body metabolism, vascular function, and cellular proteostasis. Further clinical studies are needed to confirm its safety and efficacy in preventing AD.

Keywords:
Alzheimer’s diseasecognitive functionheat shock proteinsheat therapymetabolism

More Related Videos

A Protocol for Transcranial Photobiomodulation Therapy in Mice
13:07

A Protocol for Transcranial Photobiomodulation Therapy in Mice

Published on: November 18, 2018

12.6K
Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
07:01

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

5.0K

Related Experiment Videos

Last Updated: Dec 8, 2025

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.3K
A Protocol for Transcranial Photobiomodulation Therapy in Mice
13:07

A Protocol for Transcranial Photobiomodulation Therapy in Mice

Published on: November 18, 2018

12.6K
Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
07:01

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

5.0K

Area of Science:

  • Neuroscience
  • Metabolic Health
  • Gerontology

Background:

  • Alzheimer's disease (AD) is a leading cause of neurodegeneration with no current disease-modifying treatments.
  • Metabolic and vascular conditions like type 2 diabetes and hypertension exacerbate AD pathologies.
  • Reduced proteostasis and mitochondrial dysfunction are implicated in AD etiology, with compromised heat shock protein (HSP) systems contributing to protein aggregates and impaired mitophagy.

Purpose of the Study:

  • To review the potential of heat therapy as a novel treatment for Alzheimer's disease.
  • To explore how heat therapy addresses key pathological mechanisms in AD, including metabolic dysfunction, vascular issues, and impaired proteostasis.

Main Methods:

  • This review synthesizes existing research on heat therapy's effects on metabolic health, vascular function, and cellular processes.
  • Focuses on the role of heat shock proteins (HSPs) activated by heat therapy in improving mitochondrial function and proteostasis.
  • Examines evidence for heat therapy's impact on insulin resistance, vascular function, and interorgan communication.

Main Results:

  • Heat therapy has demonstrated efficacy in reducing systemic insulin resistance and enhancing vascular function.
  • It activates HSPs, which are crucial for maintaining mitochondrial quality control (mitophagy) and cellular proteostasis.
  • Heat therapy promotes interorgan cross talk, potentially benefiting brain health.

Conclusions:

  • Heat therapy presents a promising therapeutic strategy for Alzheimer's disease by targeting multiple pathological pathways.
  • Its ability to improve metabolism, vascular health, and cellular proteostasis suggests significant clinical potential.
  • Further clinical trials are essential to establish the safety and efficacy of heat therapy for AD prevention and treatment.