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Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Related Experiment Video

Updated: Dec 7, 2025

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

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Published on: August 26, 2017

Microscopic polyangiitis.

Daniel Tobiáš, Kristína Brázdilová, Zdenko Killinger

Vnitrni Lekarstvi

|September 25, 2020

Summary

This summary is machine-generated.

Microscopic polyangiitis (MPA) is a rare vasculitis often presenting with non-specific symptoms. Early diagnosis and treatment are crucial due to its high mortality rate.

Keywords:

ANCA cerebritis glomerulonephritis pancreatitis polyangiitis vasculitis

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Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Published on: October 7, 2018

Area of Science:

Rheumatology
Internal Medicine
Immunology

Background:

Microscopic polyangiitis (MPA) is a rare, systemic, necrotizing, pauci-immune, ANCA-associated small vessel vasculitis.
Diagnosis can be challenging due to non-specific presenting symptoms.

Observation:

A 35-year-old patient presented with migrating arthritis, fever, and a papulous rash.
This case highlights the diagnostic difficulties of MPA.

Findings:

MPA requires consideration in differential diagnoses for patients with vague symptoms.
Prompt identification is critical for effective management.

Implications:

Emphasizes the importance of considering rare systemic vasculitides in non-specific presentations.
Underscores the high mortality associated with untreated MPA, necessitating timely intervention.