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The Crosstalk Between Epigenetic Mechanisms and Alternative RNA Processing Regulation
Jian Zhang1,2, Yi-Zhe Zhang1,2, Jing Jiang3
1Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.
Frontiers in Genetics
|September 25, 2020
Summary
Epigenetic mechanisms regulate RNA processing, including alternative splicing and polyadenylation, which generate diverse messenger RNA (mRNA) isoforms. RNA processing also influences epigenetic regulators, creating a feedback loop.
Area of Science:
- Molecular Biology
- Epigenetics
- RNA Biology
Background:
- RNA processing, including alternative splicing and alternative polyadenylation, generates multiple messenger RNA (mRNA) isoforms.
- These RNA processing mechanisms are vital in higher eukaryotes for cell differentiation, development, and disease.
- Epigenetic mechanisms are increasingly recognized as regulators of co-transcriptional RNA processing.
Purpose of the Study:
- To review and summarize current knowledge on the epigenetic regulation of alternative RNA processing.
- To discuss the interplay between RNA processing and epigenetic mechanisms.
Main Methods:
- Literature review of recent studies on RNA processing and epigenetics.
- Synthesis of findings on regulatory factors (trans-acting factors, cis-sequences) and epigenetic influences.
- Analysis of feedback mechanisms between RNA processing and epigenetics.
Main Results:
- Epigenetic mechanisms dynamically regulate co-transcriptional RNA processing.
- Trans-acting factors and cis-sequences are key regulators, influenced by epigenetic states.
- Alternative RNA processing exhibits feedback regulation on epigenetic machinery.
Conclusions:
- Epigenetic regulation plays a significant role in alternative RNA processing.
- The bidirectional relationship between RNA processing and epigenetics is crucial for cellular functions.
- Further research into this interplay is essential for understanding development and disease.
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