Effects of Nasal Continuous Positive Airway Pressure on Cerebral Hemodynamics in Preterm Infants

Background: To evaluate the effects of pressure levels on cerebral hemodynamics in premature infants receiving nasal continuous positive airway pressure (nCPAP) during the first 3 days of life. Methods: Forty-four preterm infants treated with nCPAP were divided into two groups: very preterm infants [gestational age 1 (GA1), GA < 32 weeks, n = 24] and moderate/late preterm infants (GA2 group, GA 32-37 weeks, n = 20). During monitoring, pressure levels were set at 4 → 6 → 8 → 4 cmH₂O, and cerebral hemodynamics was assessed by near-infrared spectroscopy (NIRS). Vital signs, peripheral oxygen saturation (SpO₂) and transcutaneous carbon dioxide pressure (TcPCO₂) were simultaneously recorded. Results: Pressures of 4-8 cmH₂O had no significant influence on cerebral hemodynamics, TcPCO₂, SpO₂ or other vital signs. The tissue oxygenation index (TOI), the difference between oxygenated hemoglobin (ΔHbO₂) and deoxygenated hemoglobin (ΔHHb) (ΔHbD), and cerebral blood volume (ΔCBV) were all significantly positively correlated with gestational and post-natal age, with fluctuations being greater in the GA1 group. ΔHbD and ΔCBV were also significantly positively correlated with TcPCO₂. Conclusions: No significant differences were observed in cerebral hemodynamics when the nCPAP pressure was set to 4-8 cmH₂O.