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Updated: Dec 7, 2025
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Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
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Percutaneous Edge-to-Edge Mitral Valve Repair
Khung Keong Yeo1,2, Ningyan Wong1,3
1National Heart Centre Singapore, Singapore.
Korean Circulation Journal
|September 25, 2020
Summary
The MitraClip device offers a minimally invasive percutaneous edge-to-edge mitral valve repair for severe mitral regurgitation (MR). It is a well-established treatment for both functional and degenerative MR in high-risk patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Device Technology
Background:
- Severe mitral regurgitation (MR) is a significant cardiovascular condition.
- The MitraClip device, introduced in 2003, pioneered percutaneous edge-to-edge mitral valve repair.
- Over 100,000 procedures worldwide highlight its established role.
Purpose of the Study:
- To review the evolution of the MitraClip device.
- To discuss clinical studies supporting MitraClip therapy for severe MR.
- To explore the concepts of proportionate and disproportionate MR.
Main Methods:
- Review of historical development and clinical trial data of the MitraClip device.
- Discussion of current indications for percutaneous mitral valve repair.
- Analysis of MR classification (proportionate vs. disproportionate).
Main Results:
- The MitraClip is the most established percutaneous therapy for severe MR.
- Indications include symptomatic functional MR despite optimal medical therapy and high-risk degenerative MR.
- The device has been used in over 100,000 cases globally.
Conclusions:
- Percutaneous mitral valve repair with MitraClip is a key therapeutic option.
- Appropriate patient selection, considering MR type, is crucial for successful outcomes.
- Continued evolution and clinical evidence support its use in managing severe MR.
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