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[Effectiveness of gentamicin sulfate in suppurative-inflammatory processes of varying localization]
Abstract:
Antibiotic sensitivity of 486 strains of grampositive and gramnegative organisms isolated from patients with purulent infections was studied in vitro. Gentamicin was shown to be highly active as compared to kanamycin and other antibiotics against the main causative agents of purulent inflammatory infections including multiresistant E. coli, Proteus, Ps. aeruginosa, Staphylococcus. High efficiency of gentamicin in therapy of peritonitis, septic conditions, purulent postoperative wounds, infections of the urinary tract, pneumonia, etc. (197 patients) was shown. Positive results were obtained in 87.4 per cent of the cases. Side effects, such as albuminuria, hyperthermic reaction, rash, pruritus were registered in 3 per cent of the patients.
Insights
Gentamicin demonstrated high effectiveness against Gram-positive and Gram-negative bacteria causing purulent infections. This antibiotic showed significant success in treating various infections with minimal side effects in patients.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Purulent infections pose a significant clinical challenge.
- Multidrug-resistant organisms are a growing concern in treating these infections.
Purpose of the Study:
- To evaluate the in vitro antibiotic sensitivity of Gram-positive and Gram-negative organisms from purulent infections.
- To assess the clinical efficacy and safety of gentamicin in treating various purulent infections.
Main Methods:
- In vitro antibiotic sensitivity testing of 486 bacterial strains.
- Clinical trial evaluating gentamicin in 197 patients with purulent infections.
Main Results:
- Gentamicin exhibited high activity against key pathogens like E. coli, Proteus, Ps. aeruginosa, and Staphylococcus, including multidrug-resistant strains.
- Clinical treatment with gentamicin achieved positive outcomes in 87.4% of patients across diverse infections.
- Adverse effects were observed in only 3% of patients, including albuminuria and rash.
Conclusions:
- Gentamicin is a highly effective antibiotic for treating a range of purulent infections caused by Gram-positive and Gram-negative bacteria.
- Its favorable efficacy and safety profile make it a valuable therapeutic option for complex infections.