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Meniscal tissue repair with nanofibers: future perspectives
Shawn P Grogan1,2, Jihye Baek1,2, Darryl D D'Lima1,2
1Shiley Center for Orthopedic Research & Education at Scripps Clinic 10666 North Torrey Pines Road, MS126, La Jolla, CA 92037, USA.
Nanomedicine (London, England)
|September 25, 2020
Summary
Engineered nanofibrous scaffolds show promise for knee meniscus regeneration, replicating natural tissue structure and function. This review highlights electrospinning advancements and cellular strategies for effective meniscal tissue repair.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Surgery
Background:
- The knee meniscus is vital for joint health, but injuries and degeneration are common, necessitating tissue replacement.
- The meniscus's complex multiscale architecture provides unique biomechanical properties crucial for knee function.
- Current treatments for meniscal damage have limitations, driving the need for advanced regenerative strategies.
Purpose of the Study:
- To review recent advancements in electrospinning for creating nanofibrous scaffolds for meniscal regeneration.
- To assess the state-of-the-art of electrospun materials in the context of engineered meniscus tissue.
- To discuss cellular sources and experimental models relevant to meniscal tissue engineering and clinical translation.
Main Methods:
- Review of electrospinning techniques for nanofibrous scaffold fabrication.
- Analysis of current literature on electrospun materials for meniscus regeneration.
- Evaluation of cellular sources and experimental models for tissue engineering applications.
Main Results:
- Electrospinning offers a viable method to create nanofibrous scaffolds mimicking meniscus ultrastructure and composition.
- Various cell sources are being explored for their potential in meniscal tissue engineering.
- Different experimental models are employed to assess scaffold efficacy and guide translation.
Conclusions:
- Nanofibrous scaffolds generated via electrospinning are a promising avenue for meniscal tissue engineering.
- Optimizing cellular function and selecting appropriate experimental models are key for successful clinical translation.
- Future innovations in electrospinning and cell-based therapies hold significant potential for meniscal regeneration.
