Related Experiment Video
Updated: Dec 7, 2025
10:04
Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
Published on: September 28, 2019
8.7K
The expression pattern of galectins during human epidermal morphogenesis.
Efstathia Pasmatzi1, Christina Papadionysiou1, Alexandra Monastirli1
1Department of Dermatology, School of Medicine, University of Patras, Patras, Greece.
Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica
|September 25, 2020
Summary
Human fetal epidermis shows changing galectin 3 expression during development. These findings suggest galectin 3
Area of Science:
- Developmental Biology
- Immunology
- Dermatology
Background:
- Galectins are conserved proteins binding β-galactoside residues.
- Their role in human epidermal morphogenesis is largely unknown.
Purpose of the Study:
- Investigate galectin expression patterns during human epidermal development.
- Identify potential roles of galectins in epidermal morphogenesis.
Main Methods:
- Immunohistochemistry on human embryonic and adult skin biopsy specimens.
- Antibodies against galectins 1, 3, 7, and 9 were utilized.
Main Results:
- Galectin 1 showed no immunoreactivity in fetal epidermis.
- Galectin 3 immunoreactivity changed with gestational age in fetal epidermis.
- Galectins 7 and 9 expression remained constant throughout gestation.
Conclusions:
- Dynamic changes in fetal galectin 3 suggest its involvement in human epidermal morphogenesis.
- Further research may explore galectin 3 alterations in inherited skin disorders for prenatal diagnosis.
Related Concept Videos
01:56Gastrulation
64.5K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
64.5K
01:25Selectins
3.8K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.8K
01:19Cadherins in Tissue Organization
3.7K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.7K
01:10Integrins
4.9K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
4.9K