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[Morphological changes in experimental infection in guinea pigs under the influence of prodigiozan and
Abstract:
The effect of prodigiozan and S-methylmethionine on the level of histomorphological changes in the organs and tissues of guinea pigs with experimental typhoid fever, dysentery and staphylococcal infections, as well as the effect of prednizolone with respect to dysentery and staphylococcal infections were studied. In the control animals the highest histomorphological changes were observed on the 4th day after the infection in the liver, kidneys and spleen. In the animals with staphylococcal infection such changes were also observed in the lung tissue. In the animals treated with prodigiozan or S-methylmethionine in a dose of 20 mg or 0.3 ml of a 5 per cent solution respectively simultaneously with or 2 days after the infection the changes in the organs were less pronounced than those in the control. Under the effect of prednizolone used in a dose of 10 mg according to the same schedule the inflammatory-dystrophic changes in the internal organs of the animals with dysentery and staphylococcal infections were much higher as compared to the control.
Insights
Prodigiozan and S-methylmethionine reduced histomorphological changes in guinea pigs with infections. Prednisolone, however, exacerbated inflammatory-dystrophic changes in these experimental models.
Area of Science:
- Veterinary Pathology
- Infectious Diseases
- Pharmacology
Background:
- Experimental infections in guinea pigs serve as models for studying disease progression.
- Histomorphological changes in organs are key indicators of infection severity.
- Understanding drug effects on host tissues is crucial for developing treatments.
Purpose of the Study:
- To evaluate the impact of prodigiozan and S-methylmethionine on histomorphological changes in experimentally infected guinea pigs.
- To assess the effect of prednizolone on similar infection models.
- To compare the efficacy of these agents in mitigating infection-induced tissue damage.
Main Methods:
- Guinea pigs were infected with typhoid fever, dysentery, or staphylococcal bacteria.
- Histomorphological analysis of organs (liver, kidneys, spleen, lungs) was performed.
- Animals were treated with prodigiozan, S-methylmethionine, or prednizolone at specific dosages and timings.
Main Results:
- Control animals exhibited significant histomorphological changes by day 4 post-infection.
- Prodigiozan and S-methylmethionine treatment led to less pronounced organ changes compared to controls.
- Prednisolone treatment resulted in significantly higher inflammatory-dystrophic changes in internal organs.
Conclusions:
- Prodigiozan and S-methylmethionine demonstrate a protective effect against infection-induced histomorphological damage in guinea pigs.
- Prednisolone exacerbates inflammatory responses and tissue damage in experimental dysentery and staphylococcal infections.
- These findings suggest potential therapeutic roles for prodigiozan and S-methylmethionine in managing certain bacterial infections.